|
KMID : 0380620110430010110
|
|
Korean Journal of Food Science and Technology
2011 Volume.43 No. 1 p.110 ~ p.113
|
|
|
Ovalbumin Induces Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression
|
|
Lee A-Neum
Park Se-Jeong
Jeong Ae-Ri
Lee Jae-Ran
Park Hye-Jeong
Kim Soo-Jung
Min In-Soon
Youn Hyung-Sun
|
|
|
Abstract
|
|
|
|
Egg allergies are the most prevalent food hypersensitivity in children. The major egg allergens are proteins, such as ovalbumin (OVA) and ovomucoid (OVM), which are mainly contained in egg whites. OVA is the major protein in egg white, comprising 54% of the total protein content. OVA has been widely used in experimental inhalant and dietary allergy animal models, but its mechanism has not been clearly identified. In this study, we showed that OVA induced nuclear factor-κB activation. OVA also induced the expression of cyclooxygenase-2 and inducible nitric oxide synthase. These data suggest new approaches for developing efficient anti-allergic strategies.
|
|
|
KEYWORD
|
|
|
ovalbumin, egg allergy, NF-κB, cyclooxygenase-2, inducible nitric oxide synthase
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|